Vanilla Buttermilk Poundcake Recipe This is made from scratch like my grandma used to make it. Oh, I love talking about delicious desserts! So, a vanilla buttermilk pound cake is a classic treat that’s sure to satisfy your sweet tooth. It’s a moist and tender cake with a rich vanilla flavor that comes from using both vanilla extract and vanilla bean seeds. The addition of buttermilk gives it a tangy and creamy taste, making it even more irresistible. More cake recipes are available in my e-book