Jonathan Taylor’s one-yard touchdown run gave Indianapolis the lead in the fourth quarter, and the Colts withstood a final drive into the red zone by the visiting Arizona Cardinals with less than a minute left to pull out a 31-27 victory on Sunday and improve to 5-1.

The Indianapolis Colts just won an incredible game against the Arizona Cardinals in what was a slobber knocker! It was a very concerning game for the Colts secondary which let the Cardinals back ups move the rock up and down the field!

The Indianapolis Colts rally in the fourth quarter to defeat the Arizona Cardinals. Here are the winners and losers from the NFL Week 6 matchup.

What channel is Arizona Cardinals vs Indianapolis Colts game on today? How to watch NFL Week 6 football game on TV, streaming Sunday, Oct. 12, 2025.

The 4-1 Indianapolis Colts are looking to continue their hot start to the 2025 season, and next up on their schedule is the 2-3 Arizona Cardinals. The team has been busy this week making changes to their roster.

The Indianapolis Colts have some key players on their injury report entering NFL Week 6 action against the Arizona Cardinals.

NFL Week 6 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Arizona Cardinals and Indianapolis Colts.