As CRISPR continues to drive breakthroughs in medicine, agriculture, and synthetic biology, understanding its origins does more than tell an ancient story. It provides a blueprint for engineering the ...

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR ...

Natural systems such as CRISPR-associated transposons (CASTs) offer a targetable, one-step way to edit genomes.

Natural systems such as CRISPR-associated transposons (CASTs) offer a targetable, one-step way to edit genomes. However, adapting them for biomedical applications has been challenging.

September 23, 2025) Natural systems such as CRISPR-associated transposons (CASTs) offer a targetable, one-step way to edit genomes ...

WEST LAFAYETTE, Ind. — More than a decade ago, scientists harnessed a bacterial molecular machine that identifies and cuts specific sections of DNA, revolutionizing the ability to edit genes and ...

"I think what's actually driving toxicity when transposons are activated is they're making all these factors that look like a virus to the cell," says Bess Frost, a neurobiologist at Brown University ...

Endogenous retroviruses (ERVs) occupy >8% of the human genome. Aberrant resurgence of ERVs has been implicated recently in several critical pathologies. However, the possible incidence and role of ERV ...

Researchers have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the fruit fly, this transcription factor, named Traffic Jam, ...

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