ABSTRACT: Abnormal cell division leading to chromosomal instability is a hallmark of cancer development. Accurate chromosome classification Lysis plays an important role in cell division, and the ...

1 Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China 2 Department of Radiotherapy Oncology, The First People’s Hospital of Yancheng, Jiangsu, Yancheng, ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of studies ...

Neuronal apoptosis plays an essential role in the pathogenesis of brain injury after subarachnoid hemorrhage (SAH). BAP1 (BRCA1-associated protein 1) is considered to exert pro-apoptotic effects in ...

Long noncoding RNAs (lncRNAs) have recently been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Cancer remains a major cause of morbidity and mortality worldwide, and while current ...

p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the switch from p53-induced cell-cycle arrest to apoptosis remains poorly understood. We unexpectedly identify a critical ...