eLife

The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis

This study offers useful findings demonstrating the cartilage-protective effects of osteoactivin in inflammatory experimental models. The study provides compelling evidence that osteoactivin may serve ...
C&EN

Bioactive Polyurethane Shape Memory Polymer Foam Dressings with Enhanced Blood and Cell Interactions for Improved Wound Healing

Polyurethane (PUr) shape memory polymer (SMP) foams have demonstrated excellent bleeding control in traumatic wounds. Unlike the current clinically available treatment options, PUr SMP foams can ...
Cancer Research

American Association for Cancer Research

Treatment with a BRAF inhibitor of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation has an estimated 5-year survival rate of 34%, with 19% being progression free. To improve ...
eLife

Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

In this valuable study, Seidel et al. identify and characterize a novel subset of hepatocellular carcinoma patient-derived xenograft models defined by active Jagged 1-Notch2 signaling and a ...
The Lancet

Homozygous variant in translocase of outer mitochondrial membrane 7 leads to metabolic reprogramming and microcephalic osteodysplastic dwarfism with moyamoya disease

aInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan bDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National ...
The Lancet

Therapeutic single-cell landscape: methotrexate exacerbates interstitial lung disease by compromising the stemness of alveolar epithelial cells under systemic inflammation

bGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea cSamsung Genome Institute, Samsung Medical Center, ...
C&EN

Optimizing Spectronaut Search Parameters to Improve Data Quality with Minimal Proteome Coverage Reductions in DIA Analyses of Heterogeneous Samples

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