Zhang et al. present important findings that reveal a new role for TET2 in controlling glucose production in the liver, showing that both fasting and a high-fat diet increase TET2 levels, while its ...

The Royal Society is a self-governing Fellowship of many of the world's most distinguished scientists drawn from all areas of science, engineering and medicine, and is the oldest scientific academy in ...

1 Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA 2 USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA Correspondence to Dr Agneta ...

One of the most confusing aspects for patients with type 2 diabetes mellitus is that they have high fasting glucose levels. This is because in these insulin-resistant patients, glucose production by ...

Lactate is converted to pyruvate by the enzyme lactate dehydrogenase in the cytosol of liver or kidney cells, producing NADH. Pyruvate is then converted to glucose by gluconeogenesis. In muscle cells, ...

The Cori cycle is a natural, metabolic pathway that was named after its discoverers, Carl Ferdinand Cori and Gerty Cori in 1929. It is sometimes referred to as the lactic acid cycle because it ...

Background: Paternal lifestyle, stress and environmental exposures play a crucial role in the health of offspring and are associated with non-genetic inheritance of acquired traits, however the ...

Yale researchers investigating the mechanism of the diabetes drug metformin have now elucidated a model for the drug and how it functions to treat Type 2 diabetes. The research study was published in ...

aMonash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia Bacterial infections that were once easily cured have ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Microbes face a series of fundamental ...