BMJ Evidence-Based MedicineOpinion

FDA approval of benzgalantamine exposes flaws in the 505(b)(2) pathway for innovations on existing drugs

When the US Food and Drug Administration (FDA) approved benzgalantamine (Zunveyl) in July 2024 for Alzheimer’s disease, it ...
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Special tests for assessing meniscal tears within the knee: a systematic review and meta-analysis

Background Musculoskeletal knee pain is a large and costly problem, and meniscal tears make up a large proportion of diagnoses. ‘Special tests’ to diagnose torn menisci are often used in the physical ...
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Of studies, syntheses, synopses, and systems: the “4S” evolution of services for finding current best evidence

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83 Navigating perceived overdiagnosis and overtreatment: experiences of those who make an active decision to decline screening or treatment along the NHS Breast Screening ...

Background Cancer screening programmes have the potential to reduce mortality, but screening programmes can also involve harms such as overdiagnosis and overtreatment. Significant rates of ...
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Critical appraisal of qualitative research: necessity, partialities and the issue of bias

Correspondence to Dr Veronika Williams, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK; veronika.williams{at}phc.ox.ac.uk Given its scope and its place ...
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Clinical expertise in the era of evidence-based medicine and patient choice

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Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum

Correspondence to Professor Kari A O Tikkinen, Department of Urology, Helsinki University Hospital, Helsinki 00290, Finland; kari.tikkinen{at}helsinki.fi To practice high quality healthcare, ...
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7 Paediatric flatfeet intervention is common, but is it evidence based?

Objectives Paediatric flatfoot is a common presentation with prevalence estimates of 15%. Some flatfeet can result in pain and altered gait. No optimal strategy, nor consensus, for non-surgical ...
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Treatment of thoracolumbar burst fractures using orthosis versus no orthosis

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131 Difficulties faced by early career researchers engaged in overdiagnosis research and solutions for overcoming them

Overdiagnosis is a counterintuitive topic that challenges aspects of conventional medicine, the intuitive belief in early detection, and society’s deep faith in medical technology. It goes against ...
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83 Fashioning change in health care: the adoption and assimilation of technology

Objectives The introduction of change, in particular where it carries a strong sense of innovation, remains a contested area of knowledge and practice. In health care, where expectations associated ...
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Reducing low value care: opportunities and challenges for Choosing Wisely campaigns

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