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FDA approval of benzgalantamine exposes flaws in the 505(b)(2) pathway for innovations on existing drugs

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Combination fixed-dose β agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review

Background In people with mild asthma poor adherence to regular therapy is common and increases the risk of exacerbations, morbidity and mortality. The use of fixed-dose combination inhalers ...
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Metro Mapping: development of an innovative methodology to co-design care paths to support shared decision making in oncology

Correspondence to Professor Anne Stiggelbout, Medical Decision Making, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands; a.m.stiggelbout{at}lumc.nl ...
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Clinical trial design and treatment effects: a meta-analysis of randomised controlled and single-arm trials supporting 437 FDA approvals of cancer drugs and indications

Objectives This study aims to analyse the association between clinical trial design and treatment effects for cancer drugs with US Food and Drug Administration (FDA) approval. Design Cross-sectional ...
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Dynamic intervention strategies await inclusion in clinical evidence synthesis

Correspondence to Dr Peiming Zhang, Department of Acupuncture and Moxibustion, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong 528000, China; 20202110151{at}stu.gzucm.edu.cn If you ...
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Teaching clinicians shared decision making and risk communication online: an evaluation study

Objectives To describe the development and initial evaluation of a brief e-learning course as a means of teaching shared decision making and risk communication skills to clinicians of all specialties.
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Of studies, syntheses, synopses, and systems: the “4S” evolution of services for finding current best evidence

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Clinical expertise in the era of evidence-based medicine and patient choice

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Reducing low value care: opportunities and challenges for Choosing Wisely campaigns

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007 Leveraging artificial intelligence to prevent overdiagnosis: a machine learning approach for predicting risk of severe dengue

Background Dengue is a significant global health threat, with nearly half of the world’s population at risk. Approximately 75% of the global dengue burden is concentrated in the Southeast Asia and ...
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83 Navigating perceived overdiagnosis and overtreatment: experiences of those who make an active decision to decline screening or treatment along the NHS Breast Screening ...

Background Cancer screening programmes have the potential to reduce mortality, but screening programmes can also involve harms such as overdiagnosis and overtreatment. Significant rates of ...
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Component network meta-analysis in a nutshell

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