Because indolent systemic mastocytosis (ISM) can affect many organs, there can be a wide variety of symptoms. You may have ...

Advanced systemic mastocytosis is a progressive disorder that causes the atypical buildup of mast cells in different organs in the body. Treatment aims to slow the progression of the condition and ...

Medically reviewed by Marla Anderson, MD Indolent systemic mastocytosis (ISM) symptoms appear when mast cells release ...

Advanced systemic mastocytosis is a progressive condition characterized by the accumulation of mast cells in the body’s organs. There’s no cure for advanced systemic mastocytosis, but many of the ...

A diagnosis of advanced systemic mastocytosis (advSM), a rare blood disorder in which too many mast cells accumulate in various parts of the body, can cause a range of strong emotions. AdvSM sometimes ...

Mastocytosis is a group of rare haematological disorders characterised by an abnormal accumulation of clonal mast cells in the skin or other organs, particularly the bone marrow. The condition ...

A drug made by Blueprint Medicines markedly improved symptoms of a rare immune system disorder called non-advanced systemic mastocytosis in a clinical trial that is being closely watched by investors, ...

The predominant presentation of this mast-cell disorder is development of pruritic lesions—especially after rubbing or exposure to heat. A 2-year-old girl presented with a history of several brown ...

Systemic mastocytosis is a myeloid neoplasm divided into six subcategories by the recent classification by WHO. It involves the accumulation of abnormal mast cells (MCs) in the skin, liver, spleen, ...

For people with indolent systemic mastocytosis (ISM), their bodies make too many mast cells—these cells are part of the immune system, so people with ISM often experience severe reactions (anaphylaxis ...