When cancer cells begin to die within tumors, they expose signals on their surface that indicate they are dying. Macrophages then detect these signals and engage in phagocytosis, where they eat the ...

Macrophages serve as the Swiss army knives of the innate immune system, switching between phenotypes to perform different functions in response to the surrounding environment. One of their key ...

Macrophages are versatile immune cells, tasked with cleaning up pathogens and maintaining tissue health. But within the tumor microenvironment, they often shift into an M2-like state—one that ...

New research from Indiana University School of Medicine scientists has revealed that a well-known cancer-fighting gene also ...

Macrophages are a type of white blood cell that are among the body's first line of defense against infection. In addition to killing harmful microorganisms, macrophages typically can initiate a ...

A novel therapy that reprograms immune cells to promote antitumor activity helped shrink hard-to-treat prostate and bladder cancers in mice, according to new research. A novel therapy that reprograms ...

A research team led by Haruka Wada, associate professor at Hokkaido University’s Institute for Genetic Medicine, examined the mechanisms by which cancer stem cells evade immune response in mice models ...

M1 and M2 are activated macrophages that protect our immune system and maintain homeostasis. Interestingly, they are characterized by distinct and opposing phenotypes. M1 macrophages are known for ...

Metastasis, or cancer spreading, is complex and still largely mysterious. As a tumor grows, it interacts constantly with the surrounding environment, including blood vessels, signaling molecules, and ...

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors. Cancer stem cells cause the aging of macrophages in mice with ...