The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand – target ...
Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a ...
Epigenetics refers to the complex series of mechanisms that regulate gene expression without changes to the underlying DNA sequence, determining heritable variations that ultimately define different ...
Agilent Technologies Inc. has announced it has added optimized target deconvolution capabilities to its powerful MassHunter Workstation Software. MassHunter Quantitative Analysis software with Target ...
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