Learn which TV channel or how to live stream the NFL Week 15 San Francisco 49ers and Tennessee Titans game, Sunday, Dec. 14.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The two AFC West squads will face off in the desert on Sunday afternoon. After six weeks of dealing with turf toe, San Francisco 49ers quarterback Brock Purdy will be back in action on Sunday, Nov. 16 as his team travels to take on the Arizona Cardinals.

Now the San Francisco 49ers look like a team that might be peaking at the right time. Purdy threw three touchdown passes, Christian McCaffrey had two rushing touchdowns and a receiving score, and the 49ers beat the sloppy Arizona Cardinals 41-22 on Sunday.

On Sunday, Brock Purdy and Ricky Pearsall returned to the offensive lineup for the San Francisco 49ers. Purdy looked like he hadn't missed any time at all, as the offense dominated. The defense wasn't great, but they were good enough to win the game ...

The San Francisco 49ers host the Carolina Panthers on Monday Night Football in a key battle for NFC playoff positioning.

The 49ers’ offense was more healthy for a full game than at any point since the 2023 NFL season. And they turned to their stars during their 41-22 victory over the Arizona Cardinals on Sunday at State Farm Stadium. The 49ers featured a lot of Brock Purdy ...

A playoff spot is within reach for the San Francisco 49ers if they take care of business vs. the Tennessee Titans on Sunday.