The San Francisco 49ers finished last in the NFL in sacks. With the defensive line hampered by Nick Bosa's absence, Bryce Huff has been drawing extra attention from opponents.

Without Williams or Pearsall, the 49ers’ offense struggled mightily against the Seahawks. After scoring 42 points the week before, San Francisco put up just 3 points against Seattle’s strong defense. Star running back Christian McCaffrey managed just 23 yards, and quarterback Brock Purdy went 19-of-27 passing for 127 yards and an interception.

Coach Shanahan and Eagles defensive coordinator Vic Fangio share a fondness for one another. They're on opposite sides here, and Coach Fangio, despite the injuries, has his hands full with the 49ers offense, one loaded with talent despite its many nicks and bruises.

The Philadelphia Eagles face the San Francisco 49ers in the Wild Card round of the 2026 NFL playoffs, a battle between two of the most storied franchises in football history. Eagles QB Jalen Hurts, who won the Super Bowl MVP Award this season, isn't overlooking the 49ers despite the team dealing with multiple defensive injuries.

There are just two days to go until the Philadelphia Eagles welcome the San Francisco 49ers to Lincoln Financial Field for what should be an explosive Wild Card

Left tackle Trent Williams and receiver Ricky Pearsall are among six players the 49ers say are questionable for Sunday's playoff matchup against the Eagles.

Over the years, 49ers fans have seen the work that Kyle Shanahan and his cadre of talented coordinators have put into the roster on full display each and every game day, and Sunday against the Philadelphia Eagles will be no different.

The San Francisco 49ers begin their 2025 playoff campaign with a trip to the reigning Super Bowl champion Philadelphia Eagles on Sunday evening. Winning the game will be a mammoth task. The 49ers have a depleted roster and could be without Trent Williams, Ricky Pearsall, and all but one linebacker.